Enhanced Interleukin (IL)-13 Responses in Mice Lacking IL-13 Receptor α 2

Enhanced Interleukin (IL)-13 Responses in Mice Lacking IL-13 Receptor α 2

Interleukin (IL)-13 has recently been shown to play important and unique roles in asthma, parasite immunity, and tumor recurrence. At least two distinct receptor components, IL-4 receptor (R)alpha and IL-13Ralpha1, mediate the diverse actions of IL-13. We have recently described an additional high affinity receptor for IL-13, IL-13Ralpha2, whose function in IL-13 signaling is unknown. To better...

IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension.

Although previous literature suggests that interleukin (IL)-13, a T-helper type 2 cell effector cytokine, might be involved in the pathogenesis of pulmonary hypertension (PH), direct proof is lacking. Furthermore, a potential mechanism underlying IL-13-induced PH has never been explored. This study's goal was to investigate the role and mechanism of IL-13 in the pathogenesis of PH. Lung-specifi...

The Murine IL-13 Receptor

A Novel Mechanism by Which Interferon- Can Regulate Interleukin (IL)-13 Responses EVIDENCE FOR INTRACELLULAR STORES OF IL-13 RECEPTOR -2 AND THEIR RAPID MOBILIZATION

Interleukin (IL)-13 mediates its activities via a complex receptor system. Interleukin-13 receptor -1 chain (IL-13R 1) binds IL-13 with low affinity, but does not signal. However, when IL-13R 1 combines with IL-4 receptor (IL-4R ), a signaling high affinity receptor complex for IL-13 is generated. In contrast, IL-13R 2 alone binds IL-13 with high affinity, but does not signal and has been postu...

Simultaneous Disruption of Interleukin (IL)-4 and IL-13 Defines Individual Roles in T Helper Cell Type 2–mediated Responses

Using a single vector targeting strategy, we have generated mice with a combined deficiency of interleukin (IL)-4 and IL-13 to clarify their roles in T helper type 2 (Th2) cell responses. Using immunological challenges normally characterized by a Th2-like response, we have compared the responses of the double-deficient mice with those generated by wild-type, IL-4-deficient, and IL-13-deficient ...